The Endomed 484 is a high-performance electrostimulator that offers TENS, NMES, and PENS therapies for pain relief, muscle stimulation and re-education, and electro-acupuncture. It has four independent channels that can be used separately, in pairs or at the same time with different programs. The TENS options include conventional, acupuncture-like, burst, and modulated TENS. The NMES feature allows for synchronous, asynchronous and alternating stimulation for muscles or muscle groups, and includes PEMS (Progressive Electrical Muscle Stimulation), which ensures that all four channels stop simultaneously for muscle stimulation in a kinetic chain. The PENS feature combines the advantages of both TENS and electro-acupuncture, using small acupuncture-like needles positioned in soft tissues and muscles for the relief of pain and functional improvement in patients. The device includes 12 evidence-based protocols, 4 fully independent channels, and stores up to 1000 favorites. It is easy-to-use with a high-resolution full-color touchscreen and can be mains-powered or battery-powered for portability. The Endomed 484 is suitable for use in various medical fields, including stroke rehab, orthopedics, sports rehab, and pelvic floor re-education.